GnRH
Pronunciation: gee-en-ar-aitch
Also written as: GnRH — gonadotropin-releasing hormone
Hormone that regulates puberty and reproductive function; commonly referenced in pediatric endocrine treatments.
Full Definition
Gonadotropin-releasing hormone, a key hormone produced by the hypothalamus that controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. In pediatric endocrinology, GnRH and its synthetic analogs play crucial roles in both diagnosis and treatment. GnRH stimulation tests help differentiate central from peripheral precocious puberty, while GnRH agonists are used therapeutically to suppress puberty in cases of precocious puberty or to pause puberty in transgender youth.
Usage
Usage note: Distinguish from GHRH (growth hormone-releasing hormone) in clinical contexts.
In Context
- "The GnRH stimulation test confirmed central precocious puberty with appropriate LH response." — Laboratory report
- "Monthly GnRH agonist injections successfully suppressed pubertal progression." — Treatment monitoring note