GnRH stimulation test
Pronunciation: G-N-R-H stim-you-LAY-shun test
Also written as: GnRH — gonadotropin-releasing hormone stimulation test
Diagnostic test measuring LH and FSH response to synthetic GnRH to assess pubertal status and hypothalamic-pituitary function.
Full Definition
A dynamic endocrine test used to evaluate the maturity and responsiveness of the hypothalamic-pituitary-gonadal axis by administering synthetic gonadotropin-releasing hormone and measuring the resulting luteinizing hormone and follicle-stimulating hormone response. The test helps distinguish between central (hypothalamic-pituitary) and peripheral causes of pubertal disorders. A robust LH response indicates pubertal activation, while a blunted response suggests prepubertal status or hypothalamic-pituitary dysfunction. Peak LH levels typically occur 30-60 minutes post-injection, with specific cutoff values established for different clinical scenarios. The test is particularly useful in evaluating suspected central precocious puberty and delayed puberty cases.
Usage
Usage note: Specify whether using leuprolide or gonadorelin as the stimulating agent.
In Context
- "The GnRH stimulation test showed a pubertal LH response with a peak of 15 IU/L." — Endocrine evaluation report
- "GnRH stimulation testing confirmed central activation in this case of early puberty." — Clinical case discussion