goitrogen
Pronunciation: GOY-tro-jen
A substance that interferes with thyroid hormone synthesis or iodine uptake, potentially causing goiter formation in children.
Full Definition
Goitrogens are compounds that disrupt normal thyroid function by interfering with iodine uptake, thyroid hormone synthesis, or thyroid hormone metabolism. In pediatric endocrinology, exposure to goitrogens through diet, medications, or environmental sources can lead to thyroid enlargement (goiter) and hypothyroidism in growing children. Common dietary goitrogens include cruciferous vegetables, soy products, and cassava. Certain medications such as lithium and amiodarone also have goitrogenic effects. Understanding goitrogen exposure is important when evaluating children with thyroid dysfunction.
Usage
Usage note: Not to be confused with 'goiter,' which is the enlargement itself.
In Context
- "The family was counseled about dietary goitrogens in their traditional cassava-based meals." — Clinical consultation note
- "Excessive consumption of goitrogenic foods may have contributed to the patient's thyroid enlargement." — Medical history