gonadotropin-independent precocious puberty
Early pubertal development caused by autonomous sex hormone production, independent of hypothalamic-pituitary activation.
Full Definition
Gonadotropin-independent precocious puberty, also known as peripheral precocious puberty or pseudoprecocious puberty, occurs when sex hormones are produced autonomously without stimulation from the hypothalamic-pituitary-gonadal axis. This condition can result from gonadal tumors, adrenal disorders, or exogenous hormone exposure. Unlike central precocious puberty, gonadotropin levels remain suppressed while sex hormone levels are elevated. The condition requires prompt evaluation to identify and treat underlying causes, which may be life-threatening. Treatment focuses on addressing the primary disorder rather than suppressing gonadotropin release.
Usage
Usage note: Distinguish carefully from central precocious puberty in documentation.
In Context
- "The suppressed gonadotropin levels confirmed gonadotropin-independent precocious puberty." — Diagnostic workup
- "Imaging revealed an ovarian tumor as the cause of her gonadotropin-independent precocious puberty." — Radiology correlation