gonadotropin independence
Condition where sexual development proceeds without stimulation from pituitary gonadotropins, typically seen in peripheral precocious puberty.
Full Definition
Gonadotropin independence refers to sexual development that occurs without stimulation from the hypothalamic-pituitary-gonadal axis. This phenomenon is characteristic of peripheral (pseudoprecocious) puberty, where sex hormone production occurs independently of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) stimulation. Causes include autonomous ovarian cysts, testicular tumors, adrenal disorders, or conditions like McCune-Albright syndrome. Unlike central precocious puberty, gonadotropin-independent sexual development does not respond to GnRH analog therapy and requires treatment directed at the underlying hormone-producing source.
Usage
Usage note: Distinguish clearly from central precocious puberty in treatment discussions.
In Context
- "The suppressed gonadotropins confirmed gonadotropin independence in this case of peripheral precocious puberty." — Laboratory interpretation
- "Testicular autonomy demonstrated gonadotropin independence, requiring surgical intervention rather than GnRH analog therapy." — Treatment planning