isolated GH deficiency
Also written as: GH — Growth Hormone
Condition where growth hormone production is impaired while other pituitary hormones remain normal.
Full Definition
Isolated growth hormone deficiency (IGHD) is characterized by insufficient growth hormone secretion from the anterior pituitary while other pituitary hormone functions remain intact. This condition can be congenital or acquired, with congenital forms often having genetic causes including mutations in GH1, GHRHR, or other genes involved in growth hormone synthesis or secretion. Acquired forms may result from tumors, infections, trauma, or radiation. Children present with short stature, delayed bone age, and characteristic facial features including a younger appearance. Treatment involves recombinant human growth hormone replacement therapy.
Usage
Usage note: Distinguish from multiple pituitary hormone deficiencies; abbreviate as IGHD when appropriate.
In Context
- "Provocative testing confirmed isolated GH deficiency with normal thyroid and adrenal function." — Diagnostic workup
- "The patient with isolated GH deficiency showed excellent response to recombinant growth hormone therapy." — Follow-up assessment