isolated gonadotropin deficiency
Condition characterized by deficient LH and FSH production with otherwise normal pituitary function, causing hypogonadotropic hypogonadism.
Full Definition
A specific form of hypogonadotropic hypogonadism where there is selective deficiency of gonadotropins (LH and FSH) while other pituitary hormones remain normal. The condition can be congenital, often associated with Kallmann syndrome when accompanied by anosmia, or acquired due to hypothalamic or pituitary lesions. Patients present with delayed or absent puberty, lack of secondary sexual characteristics, and infertility. Laboratory findings include low or inappropriately normal gonadotropin levels in the setting of low sex steroids. Treatment involves hormone replacement therapy or gonadotropin administration, depending on whether fertility is desired.
Usage
Usage note: Distinguish from Kallmann syndrome, which includes anosmia as an additional feature.
In Context
- "The diagnosis of isolated gonadotropin deficiency was supported by low LH and FSH with normal other pituitary hormones." — Endocrine consultation note
- "Isolated gonadotropin deficiency may present without anosmia in approximately half of cases." — Medical literature review