MODY
Pronunciation: MOH-dee
Also written as: MODY — Maturity-Onset Diabetes of the Young
Monogenic diabetes caused by single gene mutations affecting pancreatic beta-cell function, typically presenting in adolescence or young adulthood.
Full Definition
Maturity-Onset Diabetes of the Young (MODY) represents a group of monogenic diabetes disorders caused by mutations in genes affecting pancreatic beta-cell development or function. Unlike type 1 diabetes, MODY typically presents without autoimmune markers and may not require insulin initially. Common subtypes include MODY2 (GCK mutations) and MODY3 (HNF1A mutations), each with distinct clinical characteristics and treatment responses. Diagnosis is important as it impacts treatment decisions, family screening recommendations, and pregnancy management. Genetic testing is recommended when clinical features suggest monogenic diabetes.
Usage
Usage note: Always expand acronym on first use; specify subtype when known (MODY1, MODY2, etc.).
In Context
- "The family history and mild hyperglycemia without ketosis suggested MODY rather than type 1 diabetes." — Differential diagnosis
- "Genetic testing confirmed MODY2 with a heterozygous GCK mutation." — Genetic counseling report