somatomedin
Pronunciation: so-MAT-oh-mee-din
Growth factors, primarily IGF-1, that mediate the growth-promoting effects of growth hormone.
Full Definition
Somatomedins are a group of growth factors, primarily insulin-like growth factor 1 (IGF-1), that mediate many of the growth-promoting effects of growth hormone (GH). These peptide hormones are produced mainly by the liver in response to GH stimulation and act on various tissues to promote cellular growth and proliferation. The term 'somatomedin' was historically used before the specific identification of IGF-1 and IGF-2. In pediatric endocrinology, measuring somatomedin levels (now typically IGF-1) helps assess growth hormone activity and diagnose growth disorders. The somatomedin hypothesis explains how growth hormone exerts its effects through these intermediary factors rather than acting directly on target tissues.
Usage
Usage note: Historical term; modern usage typically refers to IGF-1 specifically.
In Context
- "Low somatomedin levels despite adequate growth hormone suggested GH resistance syndrome." — Research case report
- "The somatomedin hypothesis explains the delayed growth response to growth hormone therapy." — Medical education material