vanishing twin syndrome
Phenomenon where one fetus in a multiple pregnancy is lost early in gestation, potentially affecting endocrine development of the surviving twin.
Full Definition
Vanishing twin syndrome occurs when one fetus in a multiple pregnancy is spontaneously lost, typically during the first trimester. The phenomenon may have implications for pediatric endocrine health, particularly in the context of differences in sexual development (DSD). In some cases, the surviving twin may be exposed to hormonal influences from the lost twin, potentially affecting sexual differentiation. This is particularly relevant in XX/XY chimerism cases where the surviving female twin may exhibit virilization due to exposure to male hormones from the vanished male twin. Recognition of this syndrome is important in the evaluation of children with atypical genital development.
Usage
Usage note: Consider in DSD evaluations; obtain detailed prenatal history including early ultrasounds.
In Context
- "The patient's virilization was attributed to vanishing twin syndrome with early exposure to masculinizing hormones." — DSD evaluation
- "Maternal history revealed vanishing twin syndrome identified on early ultrasound examination." — Patient history