IFALD
Also written as: IFALD — Intestinal Failure-Associated Liver Disease
Liver dysfunction caused by prolonged intravenous nutrition in infants.
Full Definition
Intestinal Failure-Associated Liver Disease is a serious complication of prolonged parenteral nutrition, particularly common in premature infants and children with short bowel syndrome. The condition is characterized by cholestasis, hepatocellular injury, and progressive fibrosis, potentially leading to cirrhosis and liver failure. Risk factors include prolonged duration of parenteral nutrition, sepsis, and lack of enteral feeding. Management involves minimizing parenteral nutrition exposure and advancing enteral feeds when possible.
Usage
Usage note: Preferred term over PNALD (parenteral nutrition-associated liver disease) in current literature.
In Context
- "The infant developed IFALD after six months of total parenteral nutrition following extensive bowel resection." — Clinical case presentation
- "Prevention of IFALD focuses on early enteral feeding and judicious use of parenteral nutrition." — Clinical guideline