intestinal failure-associated liver disease
Progressive liver dysfunction occurring in patients with prolonged dependence on parenteral nutrition.
Full Definition
Intestinal failure-associated liver disease (IFALD) is a serious complication that develops in patients requiring long-term parenteral nutrition, particularly common in infants with short bowel syndrome or other causes of intestinal failure. The condition is characterized by progressive hepatic dysfunction, cholestasis, and potential progression to cirrhosis. IFALD represents a significant challenge in the management of pediatric patients with intestinal failure and is a primary indication for intestinal or combined liver-intestinal transplantation. The acronym IFALD is widely used in medical literature and should be clearly defined upon first use in any document.
Usage
Usage note: Commonly abbreviated as IFALD; ensure abbreviation is defined upon first use.
In Context
- "The patient developed IFALD after six months of parenteral nutrition dependence." — Gastroenterology consultation
- "Prevention of intestinal failure-associated liver disease remains a clinical priority." — Review article