protein-losing enteropathy
Also written as: PLE — Protein-Losing Enteropathy
A condition characterized by excessive loss of proteins through the gastrointestinal tract.
Full Definition
Protein-losing enteropathy (PLE) is a pathological condition characterized by excessive loss of serum proteins, particularly albumin, through the gastrointestinal tract, resulting in hypoproteinemia and often edema. In pediatric patients, PLE can result from various underlying conditions including inflammatory bowel disease, celiac disease, allergic gastroenteropathy, lymphangiectasia, or congenital heart disease. The condition presents with edema, ascites, pleural effusions, and failure to thrive due to protein malnutrition. Diagnosis involves demonstrating increased fecal alpha-1-antitrypsin or technetium-labeled albumin studies. Treatment focuses on addressing the underlying cause, protein supplementation, and dietary modifications including medium-chain triglyceride supplementation in cases of lymphatic involvement.
Usage
Usage note: Specify underlying etiology when known; distinguish from renal or hepatic causes of hypoproteinemia.
In Context
- "Elevated fecal alpha-1-antitrypsin levels confirmed protein-losing enteropathy." — Laboratory report
- "The patient's edema and hypoalbuminemia were attributed to protein-losing enteropathy secondary to IBD." — Clinical documentation