rectal biopsy
Tissue sampling procedure used to diagnose Hirschsprung disease by evaluating ganglion cell presence in bowel wall.
Full Definition
Rectal biopsy is a diagnostic procedure essential for confirming or excluding Hirschsprung disease, involving the removal of a small tissue sample from the rectal wall for histopathological examination. The biopsy must include adequate submucosal tissue to allow evaluation for the presence or absence of ganglion cells and nerve fiber patterns. Suction rectal biopsy is the preferred technique in infants and children, while full-thickness biopsy may be necessary in some cases. Proper technique and adequate tissue sampling are crucial for accurate diagnosis, as insufficient tissue can lead to inconclusive results.
Usage
Usage note: Specify technique (suction vs. full-thickness) when clinically relevant.
In Context
- "Rectal biopsy confirmed the absence of ganglion cells in the submucosal plexus." — Pathology report
- "A suction rectal biopsy was performed to evaluate for Hirschsprung disease." — Procedure note