Intermediate
Technical
IVT
hemoglobin F
Also written as: HbF — hemoglobin F
Fetal hemoglobin that protects against sickling and is a target for therapeutic intervention.
Full Definition
Hemoglobin F (HbF), also known as fetal hemoglobin, is the predominant form of hemoglobin during fetal development and early infancy. In pediatric sickle cell disease, elevated levels of HbF provide protection against vaso-occlusive crises because HbF does not participate in the sickling process. Therapeutic strategies aim to increase HbF production through medications like hydroxyurea, making HbF levels an important biomarker for treatment response and disease severity.
Usage
Usage note: Capitalize the 'F' in hemoglobin F. Commonly abbreviated as HbF in clinical contexts.
In Context
- "Elevated hemoglobin F levels were associated with fewer pain episodes in this sickle cell patient." — Clinical research study
- "The goal of hydroxyurea therapy is to increase hemoglobin F production above 20%." — Treatment guideline
Also known as
fetal hemoglobin
Don't confuse with
hemoglobin A
hemoglobin S