Intermediate
Technical
IVT
hemosiderosis
Pronunciation: HEE-moh-sid-eh-ROH-sis
Iron overload condition resulting from repeated blood transfusions or increased iron absorption.
Full Definition
The pathological accumulation of iron in tissues, particularly the liver, heart, and endocrine organs, most commonly resulting from repeated blood transfusions in chronically anemic patients. In pediatric hematology, hemosiderosis is a significant complication in patients with thalassemia, sickle cell disease, or other conditions requiring regular transfusions. The condition can lead to organ dysfunction and requires monitoring with serum ferritin levels, MRI studies, and treatment with iron chelation therapy.
Usage
Usage note: Distinguish from primary hemochromatosis, which is genetic rather than acquired.
In Context
- "Cardiac MRI revealed evidence of hemosiderosis requiring intensification of chelation therapy." — Cardiology consultation
- "The patient developed hepatic hemosiderosis after 40 units of transfused red blood cells." — Hematology follow-up note
Also known as
iron overload
transfusional iron overload
Contrasted with
iron deficiency
Don't confuse with
hemochromatosis
iron deficiency anemia