neutropenia
Pronunciation: NEW-trow-PEE-nee-ah
Abnormally low neutrophil count that increases infection risk and may be congenital or acquired.
Full Definition
A condition characterized by an absolute neutrophil count below normal age-specific values, typically less than 1,500 cells/μL in children. Neutropenia can be congenital (such as cyclic neutropenia or severe congenital neutropenia) or acquired (due to medications, infections, or autoimmune conditions). In pediatric hematology, neutropenia requires careful evaluation to determine the underlying cause and appropriate management, including infection prevention measures and possible treatment with granulocyte colony-stimulating factor (G-CSF).
Usage
Usage note: Specify absolute neutrophil count when documenting; distinguish from general leukopenia.
In Context
- "Severe neutropenia with recurrent infections prompted evaluation for congenital neutropenia syndromes." — Immunology consultation
- "Drug-induced neutropenia resolved after discontinuation of trimethoprim-sulfamethoxazole." — Medication review note