von Willebrand disease
Pronunciation: /vɒn ˈvɪləbrænt/
Also written as: VWD — von Willebrand disease
Most common inherited bleeding disorder caused by deficiency or dysfunction of von Willebrand factor affecting platelet adhesion.
Full Definition
Von Willebrand disease (VWD) is the most common inherited bleeding disorder, affecting approximately 1% of the population. It is caused by quantitative or qualitative defects in von Willebrand factor (VWF), a large multimeric glycoprotein essential for primary hemostasis. VWD is classified into three main types: Type 1 (partial quantitative deficiency), Type 2 (qualitative defects with four subtypes), and Type 3 (complete deficiency). Clinical manifestations include mucocutaneous bleeding, easy bruising, and prolonged bleeding after trauma or surgery. Diagnosis requires specialized coagulation testing including VWF antigen, ristocetin cofactor activity, and factor VIII levels.
Usage
Usage note: Do not capitalize 'von' unless at beginning of sentence. Can abbreviate as VWD. Include type classification when known.
In Context
- "The patient was diagnosed with Type 1 von Willebrand disease based on low VWF levels." — Hematology consultation
- "Family history of heavy menstrual bleeding suggested possible von Willebrand disease inheritance." — Adolescent gynecology note