conditioning regimen
Preparative treatment protocol used before hematopoietic stem cell transplantation to suppress immunity and create space for donor cells.
Full Definition
A conditioning regimen is the preparative treatment given to patients before hematopoietic stem cell transplantation (HSCT), typically involving chemotherapy and/or radiation therapy. The regimen serves to suppress the patient's immune system to prevent rejection of donor cells, eradicate abnormal immune cells, and create physical space in the bone marrow for engraftment. In pediatric immunodeficiency patients, conditioning may be reduced-intensity or ablative depending on the specific condition and patient factors.
Usage
Usage note: Specify intensity level (reduced-intensity, myeloablative) and agents used when describing regimens.
In Context
- "The reduced-intensity conditioning regimen minimized toxicity while allowing successful engraftment." — Transplant protocol
- "Conditioning regimen selection depends on the underlying immunodeficiency and patient comorbidities." — Treatment planning