CVID
Also written as: CVID — Common Variable Immunodeficiency
Common Variable Immunodeficiency, a primary immunodeficiency characterized by low antibody levels and recurrent infections.
Full Definition
Common Variable Immunodeficiency (CVID) is the most commonly diagnosed primary immunodeficiency in adolescents and adults, though it can present in childhood. The condition is characterized by hypogammaglobulinemia, poor specific antibody responses, and increased susceptibility to bacterial infections, particularly involving the respiratory tract. CVID may be associated with autoimmune complications, granulomatous disease, and increased malignancy risk. The underlying genetic cause remains unknown in most cases, and diagnosis requires exclusion of other causes of hypogammaglobulinemia. Treatment typically involves immunoglobulin replacement therapy.
Usage
Usage note: Always capitalize when using the acronym; note that despite the name, CVID is not actually the most 'common' primary immunodeficiency overall.
In Context
- "The teenager was diagnosed with CVID after presenting with recurrent pneumonia and low IgG levels." — Clinical case summary
- "Patients with CVID require lifelong immunoglobulin replacement therapy to prevent infections." — Treatment guideline