Intermediate
Technical
IVT
donor chimerism
Pronunciation: KY-mer-izm
The percentage of donor-derived cells in a transplant recipient, used to monitor engraftment success.
Full Definition
Donor chimerism refers to the proportion of donor-derived cells present in various cell lineages following hematopoietic stem cell transplantation. Chimerism analysis is performed using molecular techniques to distinguish donor from recipient cells and is essential for monitoring engraftment, detecting graft failure, and guiding post-transplant management. In pediatric immunodeficiency patients, achieving adequate donor chimerism in immune cell lineages is crucial for immune reconstitution and long-term cure.
Usage
Usage note: Specify cell lineage (T-cell, myeloid, whole blood) and percentage when reporting results.
In Context
- "Serial donor chimerism studies showed progressive increase in donor T-cell engraftment." — Post-transplant monitoring
- "Mixed donor chimerism in the myeloid lineage prompted investigation for graft rejection." — Laboratory surveillance
Also known as
engraftment analysis
chimerism testing
Contrasted with
autologous reconstitution
Don't confuse with
immune reconstitution
graft rejection