hypogammaglobulinemia
Pronunciation: hahy-poh-gam-uh-glob-yuh-lin-EE-mee-uh
Abnormally low levels of gamma globulins (antibodies) in the blood, leading to increased susceptibility to infections.
Full Definition
Hypogammaglobulinemia refers to reduced serum concentrations of immunoglobulins, particularly IgG, which compromises the body's ability to mount effective humoral immune responses. In pediatric patients, this condition can be primary (genetic) or secondary to other conditions such as protein loss, immunosuppressive medications, or malignancy. The condition predisposes children to recurrent bacterial infections, particularly of the respiratory tract and sinuses. Diagnosis is confirmed through quantitative immunoglobulin measurements, and treatment often involves immunoglobulin replacement therapy.
Usage
Usage note: Note the double 'm' in the middle of the word; often misspelled as 'hypogamaglobulinemia'.
In Context
- "Laboratory results confirmed hypogammaglobulinemia with IgG levels below the 5th percentile for age." — Laboratory report
- "The child's recurrent pneumonia was attributed to underlying hypogammaglobulinemia." — Medical record