hypogammaglobulinemia of infancy
A temporary condition of low immunoglobulin levels in infants, typically resolving as the child's immune system matures.
Full Definition
Hypogammaglobulinemia of infancy, also known as transient hypogammaglobulinemia of infancy (THI), is a temporary immunodeficiency state characterized by delayed maturation of antibody production in otherwise healthy infants. This condition occurs when maternal antibodies wane around 3-6 months of age, but the infant's own immunoglobulin production has not yet reached adequate levels. Most cases resolve spontaneously by 2-4 years of age without treatment. However, some children may experience increased susceptibility to respiratory tract infections during this period and require careful monitoring to distinguish from primary immunodeficiencies.
Usage
Usage note: Often abbreviated as THI in clinical notes; spell out the full term in formal reports.
In Context
- "The diagnosis was hypogammaglobulinemia of infancy based on age-appropriate T-cell function and family history." — Immunology consultation report
- "Serial monitoring confirmed resolution of hypogammaglobulinemia of infancy by age 3 years." — Long-term follow-up note