immune reconstitution
The recovery of immune function following treatment, particularly after bone marrow transplantation or gene therapy in immunodeficient children.
Full Definition
Immune reconstitution refers to the restoration of normal immune function in patients who have undergone treatments for primary immunodeficiencies. This process is most commonly observed following hematopoietic stem cell transplantation (HSCT) or gene therapy, where new immune cells gradually populate the patient's system and begin functioning normally. The reconstitution process typically occurs in phases, with innate immunity recovering first, followed by adaptive immunity. Complete immune reconstitution can take months to years and is monitored through serial immune function testing, including lymphocyte counts, immunoglobulin levels, and vaccine responses.
Usage
Usage note: Prefer 'immune reconstitution' over 'immunologic reconstitution' in pediatric contexts.
In Context
- "Immune reconstitution was evidenced by rising CD4+ T-cell counts six months post-transplant." — Post-transplant monitoring report
- "Complete immune reconstitution allowed discontinuation of prophylactic antibiotics after two years." — Long-term follow-up documentation