KRECs

Full Definition

Kappa-deleting recombination excision circles (KRECs) are circular DNA molecules formed during B-cell receptor gene rearrangement in developing B cells. They serve as markers of recent bone marrow B-cell output and are increasingly used in newborn screening to detect agammaglobulinemia and other B-cell deficiencies. KRECs complement TRECs testing to provide a more comprehensive assessment of lymphoid development.

Usage

Usage note: Always use plural KRECs in clinical contexts; distinguish from TRECs in screening reports.

In Context

• "Combined TRECs and KRECs screening detected both T-cell and B-cell lymphopenia in the newborn." — Diagnostic protocol
• "Low KRECs levels suggested impaired B-cell development requiring further immunologic workup." — Clinical assessment