live attenuated vaccine
A vaccine containing weakened live pathogens, contraindicated in most immunocompromised children due to risk of causing disease.
Full Definition
A live attenuated vaccine contains pathogens that have been weakened in the laboratory but remain alive and capable of limited replication. These vaccines typically provide robust, long-lasting immunity in healthy individuals but pose significant risks to immunocompromised children who may develop severe or disseminated infections from the vaccine strains. Common live attenuated vaccines include measles-mumps-rubella (MMR), varicella, rotavirus, and live influenza vaccine. In pediatric immunology practice, these vaccines are generally contraindicated in children with primary immunodeficiencies, and alternative inactivated vaccines should be used when available.
Usage
Usage note: Always hyphenate 'live-attenuated' when used as a compound adjective.
In Context
- "Live attenuated vaccines are contraindicated in this patient with severe combined immunodeficiency." — Vaccination consultation note
- "The family was counseled about avoiding live attenuated vaccines until immune function improves." — Patient education documentation