lymphocyte subset analysis
Laboratory evaluation of different lymphocyte populations using cell surface markers to assess immune system function.
Full Definition
A comprehensive immunological assessment that determines the numbers and percentages of various lymphocyte populations, including T cells, B cells, and natural killer cells, along with their functional subsets. This analysis typically employs flow cytometry with specific antibody panels to identify cell surface markers such as CD3, CD4, CD8, CD19, and CD56. In pediatric immunology, lymphocyte subset analysis is fundamental for diagnosing primary immunodeficiencies, monitoring immune development, and assessing treatment responses. Results must be interpreted using age-appropriate reference ranges, as lymphocyte populations change significantly during childhood development.
Usage
Usage note: Distinguish from simple lymphocyte counts; emphasize the subset characterization aspect.
In Context
- "Lymphocyte subset analysis demonstrated absent T cells and normal B-cell numbers, suggesting SCID." — Diagnostic workup report
- "Serial lymphocyte subset analysis tracked immune reconstitution progress over six months." — Follow-up laboratory summary