PID
Also written as: PID — Primary Immunodeficiency
Primary immunodeficiency disorders, genetic conditions causing impaired immune system function from birth.
Full Definition
Primary immunodeficiency diseases (PID) encompass over 450 distinct genetic disorders that affect the development or function of the immune system. Unlike secondary immunodeficiencies, PIDs are inherited conditions present from birth, though symptoms may not appear until later in childhood or even adulthood. These disorders can affect various components of immunity including T-cells, B-cells, antibodies, complement system, or phagocytic cells. Early recognition and appropriate treatment are crucial for preventing serious complications and improving long-term outcomes in pediatric patients.
Usage
Usage note: In immunology contexts, distinguish from 'PID' meaning pelvic inflammatory disease in gynecology.
In Context
- "The patient was referred to pediatric immunology for evaluation of possible PID." — Referral letter
- "Newborn screening programs now include testing for several forms of PID." — Public health bulletin