Professional
Technical
IVT
transient hypogammaglobulinemia of infancy
A temporary delay in immunoglobulin production that typically resolves by 18-24 months of age.
Full Definition
A common immunodeficiency condition in infants characterized by delayed maturation of B-cell function and antibody production. Unlike permanent immunodeficiencies, this condition typically resolves spontaneously as the immune system matures. Affected infants may experience increased susceptibility to respiratory tract infections but generally have normal cellular immunity. The condition requires careful monitoring to distinguish it from more serious permanent immunodeficiencies.
Usage
Usage note: Always specify 'of infancy' to distinguish from other forms of hypogammaglobulinemia.
In Context
- "The pediatric immunologist suspected transient hypogammaglobulinemia of infancy given the patient's age and clinical presentation." — Clinical assessment report
- "Serial immunoglobulin measurements confirmed resolution of the transient hypogammaglobulinemia of infancy by 20 months of age." — Follow-up laboratory report
Also known as
THI
transient immunodeficiency of infancy
Contrasted with
permanent immunodeficiency
congenital agammaglobulinemia
Don't confuse with
hypogammaglobulinemia
CVID
X-linked agammaglobulinemia