trough level
The lowest concentration of immunoglobulin in the blood, typically measured just before the next scheduled dose.
Full Definition
A pharmacokinetic measurement representing the minimum serum concentration of immunoglobulin achieved between doses of replacement therapy. Trough levels are critical for monitoring the adequacy of immunoglobulin replacement therapy and adjusting dosing regimens. In pediatric immunology practice, trough levels are typically drawn just before the next scheduled infusion and are used to ensure therapeutic targets are maintained. The measurement helps clinicians balance efficacy with safety, avoiding both under-treatment and over-treatment of immunodeficiency conditions.
Usage
Usage note: Always specify the medication or parameter being measured (e.g., 'immunoglobulin trough level').
In Context
- "The immunoglobulin trough level was 650 mg/dL, indicating adequate replacement therapy." — Laboratory results interpretation
- "Serial trough levels were monitored to optimize the immunoglobulin dosing regimen." — Treatment monitoring protocol