vaccine nonresponder
An individual who fails to develop protective immunity following standard vaccination, often indicating underlying immunodeficiency in children.
Full Definition
A vaccine nonresponder is a person who does not develop adequate antibody levels or cellular immune responses after receiving appropriate vaccinations according to recommended schedules. In pediatric immunology, vaccine nonresponse can be an early indicator of primary immunodeficiency, particularly antibody deficiencies or combined immunodeficiencies. Assessment typically involves measuring specific antibody levels 4-6 weeks after vaccination or conducting functional antibody assays. Nonresponse to protein antigens (like tetanus or diphtheria) or polysaccharide vaccines (like pneumococcal) may suggest different types of immune dysfunction and guide further diagnostic evaluation.
Usage
Usage note: Write as one word 'nonresponder' rather than 'non-responder' in medical contexts.
In Context
- "The child was identified as a vaccine nonresponder after failing to develop protective titers to multiple antigens." — Immunodeficiency screening report
- "Being a vaccine nonresponder prompted comprehensive evaluation for primary immunodeficiency." — Clinical assessment documentation