chronic granulomatous disease
Primary immunodeficiency characterized by defective neutrophil function leading to recurrent severe infections.
Full Definition
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder caused by defects in the NADPH oxidase complex, resulting in neutrophils that cannot effectively kill certain bacteria and fungi. Children with CGD experience recurrent, severe infections particularly with catalase-positive organisms such as Staphylococcus aureus, Aspergillus species, and certain gram-negative bacteria. The condition is characterized by chronic inflammatory responses and granuloma formation. Early diagnosis is crucial as patients require prophylactic antibiotics, antifungals, and careful monitoring for infectious complications.
Usage
Usage note: Define fully before using CGD abbreviation. Emphasize 'chronic' and 'granulomatous' as key descriptive elements.
In Context
- "The patient's recurrent abscesses and unusual organisms prompted testing for chronic granulomatous disease." — immunology consultation
- "Chronic granulomatous disease should be spelled out in full before using the CGD abbreviation." — medical writing standard