neonatal sepsis
Severe infection in newborns within first 28 days of life, classified as early-onset or late-onset.
Full Definition
Neonatal sepsis is a serious bloodstream infection occurring in infants during the first 28 days of life, classified into early-onset (≤72 hours) and late-onset (>72 hours) forms. Early-onset sepsis typically results from maternal transmission of organisms such as Group B Streptococcus and E. coli, while late-onset sepsis often involves nosocomial pathogens or community-acquired organisms. The condition presents with nonspecific symptoms including temperature instability, feeding difficulties, lethargy, and respiratory distress. Prompt recognition and empirical antibiotic therapy are essential given the high morbidity and mortality rates in this vulnerable population.
Usage
Usage note: Always specify early-onset or late-onset when applicable. Use standard abbreviations EOS/LOS after definition.
In Context
- "The neonate's clinical deterioration raised concern for early-onset neonatal sepsis." — NICU admission note
- "Specify early-onset versus late-onset when documenting neonatal sepsis for appropriate protocols." — neonatal care guideline