chronic kidney disease
Progressive loss of kidney function over months to years, staged by glomerular filtration rate and classified differently in pediatric populations.
Full Definition
Chronic kidney disease (CKD) in children is defined as abnormalities of kidney structure or function present for more than 3 months with implications for health. The condition is staged from 1 to 5 based on estimated glomerular filtration rate, with stage 5 requiring renal replacement therapy. Unlike adults, pediatric CKD often results from congenital anomalies (CAKUT) rather than acquired diseases like diabetes. Management focuses on slowing progression, treating complications such as anemia and bone disease, and preparing for renal replacement therapy. Growth monitoring and developmental assessment are crucial components of pediatric CKD care.
Usage
Usage note: Always specify the CKD stage and emphasize growth and development concerns specific to pediatric patients.
In Context
- "Stage 4 chronic kidney disease necessitated preparation for renal replacement therapy and growth hormone evaluation." — Nephrology consultation
- "The progression from stage 3 to stage 4 chronic kidney disease occurred over 18 months despite optimal medical management." — Disease progression note