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Professional Technical IVT

FSGS

Pronunciation: F-S-G-S

Also written as: FSGS — Focal Segmental Glomerulosclerosis

A pattern of kidney damage affecting parts of some glomeruli, commonly causing nephrotic syndrome in children.

Full Definition

Focal Segmental Glomerulosclerosis (FSGS) is a histologic pattern of glomerular injury characterized by sclerosis affecting some but not all glomeruli (focal) and involving only part of each affected glomerular tuft (segmental). In pediatric nephrology, FSGS is a leading cause of steroid-resistant nephrotic syndrome and can progress to end-stage renal disease. The condition may be primary (idiopathic) or secondary to various causes including genetic mutations, viral infections, or drug toxicity.

Usage

Usage note: Always spell out on first use in patient documents.

In Context

  • "The renal biopsy confirmed FSGS with segmental sclerosis in 30% of glomeruli." — Pathology report
  • "Children with FSGS often present with steroid-resistant nephrotic syndrome." — Clinical documentation

Also known as

focal segmental glomerulosclerosis

Don't confuse with

minimal change disease membranous nephropathy
fluid overload ← Back to glossary Gitelman syndrome

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