RPGN
Pronunciation: R-P-G-N
Also written as: RPGN — Rapidly Progressive Glomerulonephritis
A severe form of glomerulonephritis characterized by rapid loss of kidney function over days to weeks.
Full Definition
Rapidly Progressive Glomerulonephritis (RPGN) is a clinical syndrome characterized by rapid deterioration of kidney function, typically occurring over days to weeks, accompanied by an active urinary sediment and often crescentic changes on kidney biopsy. In pediatric patients, RPGN can be caused by various conditions including ANCA-associated vasculitis, anti-GBM disease, or immune complex glomerulonephritis. The condition requires urgent diagnosis and treatment to prevent irreversible kidney damage and potential progression to end-stage renal disease.
Usage
Usage note: Always expand acronym on first use in clinical documentation.
In Context
- "The patient developed RPGN with a 50% decline in GFR over two weeks." — Nephrology consultation
- "Urgent kidney biopsy revealed crescentic RPGN requiring immediate immunosuppressive therapy." — Hospital discharge summary