developmental and epileptic encephalopathy
Also written as: DEE
Conditions where both seizures and underlying pathology contribute independently to cognitive and developmental impairments.
Full Definition
Developmental and epileptic encephalopathy (DEE) represents a conceptual framework recognizing that both the underlying brain dysfunction and the epileptic activity itself contribute to cognitive and developmental impairments. This terminology acknowledges that developmental delays may precede seizure onset and that controlling seizures alone may not fully address developmental issues. Examples include Dravet syndrome, Lennox-Gastaut syndrome, and various genetic epilepsies where both the underlying genetic defect and ongoing seizures impact neurodevelopment.
Usage
Usage note: Use the full term on first reference; DEE acronym acceptable in subsequent uses within same document.
In Context
- "The patient was diagnosed with DEE given both pre-seizure developmental delays and seizure-related regression." — Multidisciplinary clinic summary
- "Understanding DEE helped guide comprehensive treatment beyond seizure control alone." — Treatment planning conference