Landau-Kleffner syndrome
An epileptic encephalopathy characterized by acquired aphasia and epileptiform EEG abnormalities, typically occurring in previously normal children.
Full Definition
Landau-Kleffner syndrome (LKS) is a rare childhood epileptic encephalopathy that presents with acquired aphasia (loss of language skills) in previously normal children, typically between ages 3-8 years. The condition is characterized by continuous spike-wave discharges during sleep (CSWS) on EEG recordings, which can occur with or without clinical seizures. The language regression is often the most prominent feature, with children losing their ability to understand and/or express language. Some children also experience behavioral changes, attention difficulties, and cognitive regression. Early treatment with anticonvulsants, corticosteroids, or even surgical interventions may help preserve or restore language function.
Usage
Usage note: Always capitalize and hyphenate the eponymous name. Often abbreviated as LKS.
In Context
- "The child's sudden language regression and abnormal sleep EEG suggested Landau-Kleffner syndrome." — Pediatric neurology assessment
- "High-dose corticosteroids were initiated for suspected Landau-Kleffner syndrome with significant language loss." — Treatment plan documentation