Lennox-Gastaut syndrome
Pronunciation: LEN-ox GAS-toh
A severe childhood epilepsy syndrome characterized by multiple seizure types, slow spike-and-wave EEG pattern, and intellectual disability.
Full Definition
Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy that typically manifests between ages 1-8 years, with peak onset around 3-5 years. The syndrome is characterized by a triad of features: multiple seizure types (including tonic, atonic, absence, and generalized tonic-clonic seizures), a distinctive slow spike-and-wave EEG pattern (1.5-2.5 Hz), and cognitive impairment or developmental delay. LGS is often treatment-resistant, requiring polytherapy with antiepileptic drugs. The syndrome may evolve from other epilepsy conditions like West syndrome or arise de novo. Children with LGS frequently experience frequent falls due to drop attacks and require protective measures.
Usage
Usage note: Hyphenate the eponym. Can be abbreviated as LGS in subsequent references within the same document.
In Context
- "The child's epilepsy evolved from West syndrome to Lennox-Gastaut syndrome at age 4 years." — Epilepsy transition note
- "Lennox-Gastaut syndrome requires comprehensive management including seizure control and developmental support." — Multidisciplinary care plan