Professional
Technical
IVT
ATRT
Also written as: ATRT — Atypical Teratoid Rhabdoid Tumor
Atypical teratoid rhabdoid tumor, a rare and aggressive brain tumor occurring predominantly in very young children.
Full Definition
Atypical teratoid rhabdoid tumor (ATRT) is a rare, highly malignant brain tumor that occurs predominantly in children under 3 years of age. ATRT is characterized by loss of SMARCB1 (INI1) or rarely SMARCA4 expression and typically arises in the posterior fossa, though it can occur anywhere in the central nervous system. These tumors require intensive multimodal treatment including surgery, chemotherapy, and radiation therapy when age-appropriate.
Usage
Usage note: Always confirm INI1 or SMARCA4 status in suspected cases.
In Context
- "Pathological examination confirmed ATRT with characteristic loss of INI1 expression." — Pathology report
- "ATRT treatment protocols are being developed specifically for very young children." — Clinical trial description
Also known as
atypical teratoid rhabdoid tumor
Don't confuse with
medulloepithelioma
embryonal tumor
rhabdoid tumor