Professional
Technical
IVT
BFM protocol
Berlin-Frankfurt-Münster treatment protocol, a widely used chemotherapy regimen for pediatric acute lymphoblastic leukemia.
Full Definition
The Berlin-Frankfurt-Münster (BFM) protocol is an intensive multi-agent chemotherapy regimen developed for treating pediatric acute lymphoblastic leukemia. Originally established by the BFM study group, this protocol emphasizes early intensification and has been adapted worldwide. The BFM backbone includes specific phases of induction, consolidation, interim maintenance, delayed intensification, and maintenance therapy.
Usage
Usage note: Specify the particular BFM adaptation when possible (e.g., BFM-95, AIEOP-BFM).
In Context
- "The patient was enrolled on a BFM protocol-based study for high-risk ALL." — Treatment plan
- "BFM protocol modifications have improved outcomes while reducing toxicity in pediatric ALL." — Clinical research paper
Also known as
Berlin-Frankfurt-Münster protocol
Don't confuse with
COG protocol
UKALL protocol