consolidation therapy
Intensive treatment phase following remission induction, designed to eliminate residual cancer cells.
Full Definition
Consolidation therapy, also called intensification therapy, is a treatment phase that follows successful induction of remission in pediatric cancer protocols. The goal is to eliminate minimal residual disease that may remain after induction therapy. Consolidation typically involves high-dose chemotherapy, sometimes with stem cell rescue, and may include radiation therapy. This phase is critical for preventing relapse and achieving long-term cure, particularly in acute leukemias and high-risk solid tumors.
Usage
Usage note: Distinguish from maintenance therapy, which is lower-intensity and longer duration.
In Context
- "The patient will begin consolidation therapy following confirmation of remission." — treatment plan
- "High-dose methotrexate is a key component of the consolidation phase." — protocol document