Professional
Technical
IVT
MDS
Also written as: MDS — Myelodysplastic Syndrome
Myelodysplastic syndrome, a group of bone marrow disorders that can occur as therapy-related complications in pediatric cancer patients.
Full Definition
Myelodysplastic syndrome (MDS) refers to a group of clonal bone marrow disorders characterized by ineffective hematopoiesis and risk of transformation to acute leukemia. In pediatric oncology, MDS is most commonly encountered as a therapy-related complication (t-MDS) following treatment with alkylating agents or topoisomerase II inhibitors. Pediatric MDS differs from adult disease in presentation, underlying genetics, and treatment approaches.
Usage
Usage note: Specify therapy-related (t-MDS) versus de novo when applicable.
In Context
- "The patient developed therapy-related MDS five years after completing treatment for Hodgkin lymphoma." — Follow-up report
- "Pediatric MDS often presents with cytopenias and dysplastic changes in bone marrow cells." — Diagnostic criteria
Also known as
myelodysplastic syndrome
Don't confuse with
aplastic anemia
acute leukemia