pleomorphic
Pronunciation: plee-oh-MORE-fik
Describing cells or tissues that show variation in size, shape, and appearance, often indicating malignancy.
Full Definition
Pleomorphic refers to the morphological characteristic of cells or tissues that demonstrate significant variation in size, shape, nuclear features, and cellular architecture. In pediatric oncology, pleomorphism is an important histopathological feature used to assess tumor grade and aggressiveness. Highly pleomorphic tumors typically indicate poor differentiation and more aggressive behavior, while tumors with minimal pleomorphism suggest better differentiation and potentially better prognosis. Pathologists evaluate pleomorphism alongside other features such as mitotic activity and necrosis to determine tumor grade. The degree of pleomorphism helps guide treatment intensity and provides prognostic information for families and clinical teams.
Usage
Usage note: Always specify the degree of pleomorphism (minimal, moderate, marked) when describing tumor characteristics.
In Context
- "Histological examination revealed highly pleomorphic cells consistent with high-grade sarcoma." — Pathology report
- "The tumor showed minimal pleomorphism, suggesting a lower grade malignancy." — Histopathology review