PPHN
Also written as: PPHN — Persistent Pulmonary Hypertension of the Newborn
Persistent pulmonary hypertension of the newborn, a complication that can occur with certain pediatric cancer treatments.
Full Definition
Persistent pulmonary hypertension of the newborn (PPHN) is a condition where pulmonary vascular resistance remains elevated after birth, leading to right-to-left shunting and severe hypoxemia. In pediatric oncology, PPHN can be a treatment-related complication, particularly with certain chemotherapy agents or as a consequence of tumor lysis syndrome. Recognition and prompt management are critical as PPHN can be life-threatening.
Usage
Usage note: Context-dependent term in pediatric oncology; primarily relevant in perinatology but important for treatment complications.
In Context
- "The neonate developed PPHN following maternal exposure to chemotherapy during pregnancy." — Case report
- "PPHN should be considered in any newborn with severe hypoxemia and history of in-utero cancer treatment exposure." — Clinical guidelines