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Reed-Sternberg cell
Pronunciation: REED STERN-berg
Large abnormal lymphoid cells with distinctive morphology that are pathognomonic for classical Hodgkin lymphoma.
Full Definition
Reed-Sternberg cells are large, abnormal B-lymphoid cells that are the hallmark of classical Hodgkin lymphoma. They are characterized by their large size, abundant cytoplasm, and distinctive nuclear morphology, often with multiple nuclei or a single large multilobated nucleus. These cells typically express CD30 and CD15 but lack CD20. Variants include Hodgkin cells (mononuclear variants) and lacunar cells. The identification of Reed-Sternberg cells is essential for the diagnosis of Hodgkin lymphoma.
Usage
Usage note: Hyphenate when used as a compound modifier. Capitalize both surnames as eponyms.
In Context
- "The biopsy showed scattered Reed-Sternberg cells in a background of inflammatory cells." — Pathology report
- "Immunohistochemistry confirmed CD30-positive Reed-Sternberg cells consistent with Hodgkin lymphoma." — Diagnostic report
Also known as
RS cell
Hodgkin-Reed-Sternberg cell
Don't confuse with
Hodgkin cell
lacunar cell