congenital pseudoarthrosis of the tibia
Also written as: CPT — congenital pseudoarthrosis of the tibia
A rare condition characterized by tibial fracture and non-union that typically presents in infancy, often associated with neurofibromatosis type 1.
Full Definition
Congenital pseudoarthrosis of the tibia (CPT) is a rare pediatric orthopedic condition involving spontaneous fracture of the tibia that fails to heal, resulting in a persistent non-union or pseudoarthrosis. The condition typically manifests in the first few years of life and is strongly associated with neurofibromatosis type 1 (NF1). The affected bone shows characteristic dysplastic changes, including narrowing, sclerosis, and eventual fracture, usually in the distal third of the tibia. Treatment is challenging and often requires multiple surgical procedures including bone grafting, vascularized grafts, and external fixation.
Usage
Usage note: Often abbreviated as CPT in clinical notes, but should be spelled out in formal reports.
In Context
- "The patient's congenital pseudoarthrosis of the tibia required vascularized fibular grafting for successful union." — Case study
- "Given the family history of neurofibromatosis, screening for congenital pseudoarthrosis of the tibia was initiated." — Clinical assessment