hypoxic-ischemic injury
Lung damage resulting from inadequate oxygen delivery and blood flow, particularly in neonates.
Full Definition
Hypoxic-ischemic injury refers to lung damage caused by inadequate oxygen delivery (hypoxia) combined with reduced blood flow (ischemia) to pulmonary tissues. In pediatric patients, particularly neonates, this injury can occur during perinatal complications such as birth asphyxia, severe respiratory distress, or circulatory shock. The resulting cellular damage can lead to inflammation, impaired surfactant production, increased pulmonary vascular resistance, and potentially long-term complications including bronchopulmonary dysplasia. Early recognition and intervention are crucial to minimize the extent of injury and improve outcomes.
Usage
Usage note: Often abbreviated as HIE; context should clarify whether referring to cerebral or pulmonary injury.
In Context
- "The neonate's chest X-ray showed changes consistent with hypoxic-ischemic injury following prolonged resuscitation." — Neonatal intensive care assessment
- "Long-term follow-up revealed persistent pulmonary function abnormalities secondary to neonatal hypoxic-ischemic injury." — Longitudinal care documentation