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Professional Technical IVT

anticardiolipin antibodies

Autoantibodies against cardiolipin, a phospholipid component of cell membranes, often tested in pediatric lupus evaluation.

Full Definition

Anticardiolipin antibodies are autoantibodies directed against cardiolipin, a negatively charged phospholipid found in cell membranes and mitochondria. In pediatric rheumatology, these antibodies are part of the antiphospholipid antibody panel used to evaluate children with suspected systemic lupus erythematosus or antiphospholipid syndrome. Their presence may indicate increased risk for thrombotic events, though this is less common in children than adults. Testing involves ELISA methodology with results reported in GPL units for IgG and MPL units for IgM antibodies.

Usage

Usage note: Always specify antibody type (IgG, IgM, or IgA) when reporting results.

In Context

  • "The laboratory panel should include anticardiolipin antibodies when evaluating this adolescent for possible lupus." — Clinical assessment documentation
  • "Elevated anticardiolipin antibodies in conjunction with clinical symptoms may suggest antiphospholipid syndrome." — Diagnostic report

Also known as

aCL antibodies anti-CL

Don't confuse with

anti-beta-2-glycoprotein I lupus anticoagulant

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