anti-Jo-1 antibodies
Pronunciation: AN-tee-JOH-one
Autoantibodies against histidyl-tRNA synthetase, associated with inflammatory myopathy and interstitial lung disease in children.
Full Definition
Anti-Jo-1 antibodies are autoantibodies directed against histidyl-tRNA synthetase, an enzyme involved in protein synthesis. In pediatric rheumatology, these antibodies are most commonly associated with juvenile dermatomyositis and polymyositis, and their presence often indicates a higher risk of developing interstitial lung disease, arthritis, and other systemic manifestations. Anti-Jo-1 is one of several myositis-specific antibodies (MSAs) that help define clinical phenotypes and guide treatment decisions. Children with anti-Jo-1 positive myositis may have a more chronic disease course and require more aggressive immunosuppressive therapy. The antibodies are detected using immunoprecipitation or ELISA-based assays.
Usage
Usage note: Hyphenate 'anti-Jo-1'; capitalize 'Jo' as it's derived from a patient name.
In Context
- "Positive anti-Jo-1 antibodies prompted screening for interstitial lung disease in this child with dermatomyositis." — Laboratory result interpretation
- "The presence of anti-Jo-1 antibodies suggested a need for more aggressive immunosuppressive therapy." — Treatment planning documentation